Current challenges in identification of HIV-associated neurocognitive disorders (HAND), an overview
A high proportion of people living and ageing with treated HIV in both high and low-middle income settings meet criteria for HIV-associated Neurocognitive Disorders (HAND).
Since the majority of people living with HIV live in sub-Saharan Africa (SSA), SSA is disproportionately burdened by HAND. Despite this, HAND prevalence estimates vary greatly in SSA and elsewhere , and data synthesis is challenging with systematic reviews of prevalence demonstrating high heterogeneity. Challenges in measurement and identification of HAND appear to be a major cause of these issues. The aetiology of HAND appear complex and poorly understood. Similarly, the population of people living with HIV is ageing, and both ageing and comorbidities may affect the observed phenotype of HAND in the post CART era.
I will give a broad overview of the current challenges in this area in terms of measurement/assessment tools and changes in observed phenotype of HAND in individuals ageing with HIV, focusing on SSA. I will also compare this with the situation in cognitive impairments associated with the long COVID syndrome, with the results of a recent systematic review I have co-authored. I’ll finish with some thoughts, questions and challenges on the way forward,including some new proposed criteria.
About the Speaker
Dr Stella Paddick, Newcastle University
Please note that this is a Hybrid event. We welcome colleagues to 66 Banbury Road or on line via Zoom:
This event is part of a seminar series:
Convenor: Dr Melina Malli Please note that this is a Hybrid event. We welcome colleagues to 66 Banbury Road or on line via Zoom: https://us02web.zoom.us/j/86079626971
16 November 2023 14:00 - 15:00
Online & 66 Banbury Rd